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Ranging from serious (medical) to minor (diet), these absorption and storage issues stem from a variety of reasons

Ensure your zinc status is good (either through diet or a 10-15 mg supplement daily)

Adding a glutathione push to a Myers Cocktail session creates a synergistic protocol

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An unwanted shift from 2- to 4-hydroxyestrogen might be an additional pro-inflammatory signal because these 4-hydroxylated metabolites can be converted to 3,4-quinone, which lead to depurination and mutation in DNA